Erythrityl Tetranitrate

Indication	For the prevention of angina.
Pharmacodynamics	Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin.
Mechanism of action	Similar to other nitrites and organic nitrates, erythrityl tetranitrate is converted to an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Absorption	Not Available
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Not Available
Route of elimination	Not Available
Half life	Not Available
Clearance	Not Available
Toxicity	Symptoms of overdose include increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.

 Brand Names

Cardilate
Cardiloid
Cardivell
Cardiwell
Tetranitrin
Tetranitrol

  
Interactions

Drug Interactions	Drug Interaction Dihydroergotamine Possible antagonism of action Ergotamine Possible antagonism of action Methysergide Possible antagonism of action
Food Interactions	Avoid alcohol. Take on empty stomach: 1 hour before or 2 hours after meals.

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