| Indication | Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract. |
| Pharmacodynamics | Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally. |
| Mechanism of action | The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall compenent from being properly synthesized. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | 65-80% |
| Metabolism | Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine. |
| Route of elimination | Not Available |
| Half life | 30 minutes |
| Clearance | Not Available |
| Toxicity | Rat intravenous LD50 is 4000 mg/kg. |
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